Variability of the pharmacological response in children with different ADRB2 gene polymorphisms in recurrent bronchial obstruction and bronchial asthma

To date, methods of studying the effects drugs at molecular-genetic level are widely used in pediatric practice. The aim our work was to evaluate effectiveness effect β2-agonists on clinical course recurrent bronchial obstruction (RBO) children, depending variants polymorphism ADRB2 gene. salbutamol children with RBO and asthma(BA) evaluated distribution alleles genotypes Argl6Gly Gln27Glu genes according degree reversibility obstruction. In group carriers heterozygous A/G genotype Arg16Gly locus gene, high efficacy therapy as a bronchodilator noted. At same time, representatives G/G genotype, using drug is low. BA, change functional activity associated gene low therapeutic response β2–agonists G\G mutational good homozygous variant A/A genotype. Knowledge polymorphic will make it possible one factors predisposition syndrome asthma.